Immobilization of actively thromboresistant assemblies on sterile blood-contacting surfaces.
نویسندگان
چکیده
Rapid one-step modification of thrombomodulin with alkylamine derivatives such as azide, biotin, and PEG is achieved using an evolved sortase (eSrtA) mutant. The feasibility of a point-of-care scheme is demonstrated herein to site-specifically immobilize azido-thrombomodulin on sterilized commercial ePTFE vascular grafts, which exhibit superior thromboresistance compared with commercial heparin-coated grafts in a primate model of acute graft thrombosis.
منابع مشابه
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ورودعنوان ژورنال:
- Advanced healthcare materials
دوره 3 1 شماره
صفحات -
تاریخ انتشار 2014